Having just posted about special populations I received an email to inform me that a recent paper that was written in conjunction with Sandra Klein at the University of Greifswald has just been published.
Here is a link.
This work specifically explored the impact of malnutrition on drug absorption in children. Malnutrition affects the gastro-intestinal physiology with impacts on every stage from saliva production through the stomach and into the small intestine. These differences mean that orally administered medicines may not be absorbed in the same was as in healthy adults. Most medicines are tested in healthy adults and then the findings used to predict how they are likely to work in a range of different populations. The paper summarized the main differences and where these differences may be important for this most vulnerable population.