Assessing acceptability of medicines..

New regulations have stated that it is important to assess the acceptability of medicines designed for children but it is really difficult to know which methods to use.

I am celebrating the publication of a review article on this topic:

Methodology Used to Assess Acceptability of Oral Pediatric Medicines: A Systematic Literature Search and Narrative Review

This study looked at the range of methods used to see which are of use – hedonic scales are often used and seem to be the most appropriate but it is important that the faces match the responses from a child. Often pain scales include children crying and we very much hope that the taste of a medicine does not result in tears. There are also some cultural considerations as some scales have faces winking or sticking out the tongue which can have very different meanings for children (and adults) globally.

Image result for hedonic scale

Image result for faces scale

There are also studies that used gender specific scales but this seems to add to the confusion…

It is important to review all the information to make sure that data collected is of value

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Recycling medicines for children

Repurposing medicines is a fashionable term that is used to describe using existing medicines in new ways. This is interesting for children as often clinical studies are conducted in adults and a medicine is then used in children without the same level of evidence to support it’s use. This leave children at risk to unexpected side effects or incorrect dosing. New interest in repurposing has attracted new funding and now there are incentives to develop age-appropriate medicines for children – this can only make the clinical picture better for children going forwards.

It is time to take action and make sure that children have access to the medicines they need in a form that they can take. There are new funding streams to support this work and it is important to work collaboratively to achieve our goals.

http://www.findacure.org.uk/open-call/

 

findacure presentation

I have been invited to give a presentation on pre-clinical drug development to an audience of patient groups. This is a real challenge for me as I know a lot about pre-clinical drug development and teach this to undergraduate and post-graduate students at the University of Birmingham. However, this audience is unique, I don’t know their background knowledge so I am not sure how much to say – the presentation is a webinar so I can’t see their faces to see if my approach is at the right level. How will I know if I have given them the information they wanted…. Finally, University students’ motivation is always linked to assessment – this audience will not be assessed on their understanding!! Although they are relieved about this I still need to understand their motivation to take the time to listen and feel enormous responsibility to deliver an interesting talk…

I have worked with patient groups previously; they are representatives who are often eager to learn more about a condition that affects them or a family member. The main purpose of my talk is to explain pre-clinical research in a simple way to make sure that I introduce the language used within this area of research to enable patient groups to have meaningful conversations with researchers and funders working in this area. Patient groups can be involved in prioritisation exercises to determine where funding should be directed – it is critical that they understand the impact of that funding on the outcomes for the patient group – even when these outcomes may not have an immediate and direct effect on those living with a condition.

 

The event is on the 11th April and I have already planned the presentation – I now need to road test and fine-tune it – wish me luck

http://www.findacure.org.uk/webinars/

 

Voice of the child?!

Today I had the privilege of examining a PhD student on her research project that explored the potential to involve children in medicines R&D. This is a topic close to my heart as I really feel that children should have a voice in the development of medicines as well as their testing to ensure they meet the needs of those children who have to take the medicine. Research projects that tackle these issues are really important to highlight the role that children can play. Giving children a voice is one of the most powerful things that we can do.

I have been asked to talk at the Royal Pharmaceutical Society at an event about women in leadership. This is a subject that I don’t usually talk about and it is something that has given me cause for concern – what can I say about women in leadership what voice do I want to channel…? In my research I decided to ask my female friends for advice on what to say and what they would want to hear. So far the responses have been varied – I have enjoyed the discussions as the viewpoints are so diverse. However, this time my research has been much more enjoyable that other topics – I have been introduced to some great online resources and “The Guilty Feminist” is my new favourite podcast. http://guiltyfeminist.com/

One of the things I have learnt is that I have a voice and I can use this voice to not only speak for children but also for women – it is time that I used it.

I need to get involved and really support and champion women in pharmaceutical science. I wrote a short promotional piece for the talk at the RPS and I highlighted that although we have approximately 70% females on our undergraduate courses the proportion of women in senior roles in pharmacy is only 20%. I want to set a challenge to my audience that we all identify how we can support and champion women to make a change. I hope that I can reach out to men as well as women as it needs the support of all pharmaceutical scientists to ensure that we have an equal workplace.

I now need to seek out how we do this – will it be by mentoring, activism or do we need to take a more disruptive route – I will have to wait and see what the audience think!

 

Young people engaged in research

I received good news this week 🙂

I have recently run a research project looking at the age at which young people take responsibility for their own healthcare. We collaborated with a local school on this project and the student, who was in sixth form, became a member of our research team.

Projects like this are really exciting as young people get a real experience of research. And now for the good news…..

The research study was submitted as a conference abstract for the Royal College of Paediatrics and Child Health – the leading medical event in the UK for paediatricians – and the project has been selected to be presented at the event.

I am so excited for me, the student and his school – this is a real achievement

Making a difference

I recently published an article where we looked at strategies parents use to make administration of foul tasting medicines better for their children. We were looking at a specific medicine (flucloxacillin) in children with Cystic Fibrosis.

We gathered our data by asked 250 parents what they do to try to get a full picture and then share this with other parents, doctors, nurses and pharmacists to help other patients and their families. This was a piece of research that I really enjoyed undertaking and writing.

Over the Christmas holiday I was contacted by a parent who wanted to know more as he was struggling to administer this medicine to his child. This made me feel both sad and happy. Sad because many parents go through this daily struggle to administer medicines to their children and happy because I was able to provide some evidence based advice and to reassure him that he is not alone. It is really important that we all do more to help the end user and really make a difference. My new year’s resolution was to try to develop a better tasting version of this medicine so that in future there is another option which would really make me happy!

1960s clinical trial conducted in a school

One of the stories in the news today is about a clinical trial involving a new drug that was conducted in a school without informed consent of participants or their parents.

According to the BBC web pages it was on an anticonvulsant, which has sedative effects and was prescribed for epilepsy, is no longer widely in use. It was to be a “double blind” trial, with a control group given a placebo, and another group given the drug. The drug would be administered to disruptive pupils aged 15 and older.  According to the news source, the trial went ahead in 1968, with boys given the drug for six months. There is no record of the outcome in the documents, nor was any published paper in medical journals found.

It is this type of story which damages the reputation of many involved in clinical research; the lack of transparency and then the lack of reporting the outcome. It is really important to highlight this type of story but more important is the ability of researchers now to respond and highlight how much times have changed and to use this information to promote clinical research. I am awaiting the responses from the experts…..